منابع مشابه
Response of methylenetetrahydrofolate levels to methotrexate in Krebs ascites cells.
Levels of methylenetetrahydrofolate in Krebs ascites cells subsequent to transplantation and the effects of methotrexate on these levels have been measured. To directly measure methylenetetrahydrofolate in tissue extracts, the cofactor was incorporated into a covalent ternary complex with thymidylate synthase and 3H-labelled fluorodeoxyuridine monophosphate. A 3-4-day lag preceded rapid growth ...
متن کاملThin layer chromatography of Krebs cycle acids.
A systematic appraisal of a large number of solvent systems was carried out for the separation of lactic, pyruvic and 3-hydroxybutyric acids and all of the KREBS cycle acids, except oxalosuccinic, using silica gel G and cellulose thin layer Chromatographie plates. Four solvent systems which allowed separation of various combinations of acids are described and the limits of this method of separa...
متن کاملKrebs cycle anions in metabolic acidosis
For many years it has been apparent from estimates of the anion gap and the strong ion gap that anions of unknown identity can be generated in sepsis and shock states. Evidence is emerging that at least some of these are intermediates of the citric acid cycle. The exact source of this disturbance remains unclear, because a great many metabolic blocks and bottlenecks can disturb the anaplerotic ...
متن کاملSeifert Fibered Homology 3 - Spheres Mike Krebs
To each connected component in the space of semisimple representations from the orbifold fundamental group of the base orbifold of a Seifert fibered homology 3-sphere into the Lie group U(2, 1), we associate a real number called the “orbifold Toledo invariant.” Using the theory of Higgs bundles, we explicitly compute all values this invariant takes on.
متن کاملRetrospective. Edwin G. Krebs (1918-2009).
537 PERSPECTIVES E dwin G. Krebs, a giant of biomedical science in the 20th century, died on 21 December from congestive heart failure in Seattle at the age of 91. His discovery (with Edmond H. Fischer) of protein phosphorylation as a regulatory mechanism touched all aspects of biomedical science and profoundly infl uenced therapeutic approaches now used in clinical care. Ed's life epitomizes c...
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ژورنال
عنوان ژورنال: BioScience
سال: 2001
ISSN: 0006-3568
DOI: 10.1641/0006-3568(2001)051[0605:rfk]2.0.co;2